DEPARTMENT OF AGRICULTURE April 30, 1990
Administrative Order No. 60
DEPARTMENT OF HEALTH
Administrative Order No. 91
SUBJECT : DECLARING A BAN ON THE USE OF CHLORAMPHENICOL IN FOOD
Chloramphenicol is an active ingredient of drug products with a proven value as an antibiotic for life threating infections in humans. It is also being used by mixing with feed for animals raised as food.
3.1 Chloramphenicol is a useful drug for treating infections in humans. Its value however, requires that it be used discriminately through physicians prescription after a sound diagnosis.
3.2 When used in animals raised for food, chloramphenicol residues build up in animal tissues that are eventually ingested by humans when these are consumed. The human tolerance for such residues cannot be established because the effect may or may not be related to the dose or the duration of exposure. In fact, the joint FAO/WHO Expert Committee on Food Additives has not recommended an acceptable residue level since no assurance can be given that even low residue levels would be safe for certain sensitive individuals.
3.3 Indiscriminate or even discriminate use of chloramphenicol in food producing animals can lead to build-up of residues in food derived from such animals causing (a) increased chance of human exposure to possibility of aplastic anemia, one of the rare but fatal conditions associated with chloramphenicol, and (b) alteration of microbial ecology leading to increased chloramphenicol-resistance of human pathogens.
Now, therefore, we the Secretariats of Agriculture and Health, jointly and several order the following:
(Sgd.) ALFREDO R.A. BENGZON, M.D. (Sgd.) SENEN C. BACANI
Department of Health Department of Health
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